Is It True That Breast Cancer Due To The Lineage?

Is It True That Breast Cancer Due To The Lineage?

     The WHO data mentions that in 2011 there are at least 508 thousand women who died of breast cancer. Whereas in Indonesia itself, the data of the Ministry of Health said that the incidence of breast cancer in Indonesia reached 0.5 per 1000 women in 2013. Moreover, early detection of women of productive age in the 644,951 has been performed by the Ministry of health since the years 2007 to 2013 and found as many as there are 1,682 women whose lumps on her breasts.

     In General, women her age has exceeded 50 years, has a chance of developing cancer of the breast is higher compared with women who are younger. Then, is it true that breast cancer can be lowered?

Gene's relationship with cancer

Cancer can occur due to wrong in making the ' code ' when does DNA replication, it is called mutation genes. Gene Mutation can happen to anyone and at any time in our life. Most people affected by cancer at a young age, maybe a gene mutation has occurred in the past due to the stimulus and trigger from environmental factors. But it takes a long time, therefore the majority of people have cancer in old age or in adults. Cancer can also be caused due to heredity, gene mutation had occurred in previous generations and are passed down to the next generation.

Breast cancer because the offspring

    Women who have a mother, grandmother, sister, or aunt ever exposed breast cancer breast cancer a chance to experience two to three times higher than women who do not have a history of breast cancer in his family. There are 5 to 10% the incidence of breast cancer is caused by the descent. This is related to the genes BRCA1 and BRCA2 mutation which has undergone subsequently handed down by parents to the next generation. BRCA1 and BRCA2 gene is a man who is often referred to as tumor suppressor genes whose function is to control the growth of cell Mutation. that occurred on this gene will cause the appearance of cancer cells.  

    In fact, every woman have the genes BRCA1 and BRCA2 that are designed to fix a broken breast cells and normal cells that store. A woman who has the genes BRCA1 or BRCA2 mutations, which has undergone a risk increased by 80% to have breast cancer. However, not always women with a BRCA1 or BRCA2 gene termutasi experiencing breast cancer.

    BRCA1 and BRCA2 gene mutations can increase the chances of developing cancer of the breast. BRCA1 and BRCA2 gene mutations can be lowered by a father or mother who became a ' carrier ' of these genes. As many as 50% of parents who become carriers of the gene mutation gene, the gene to his son lowered even to the next generation.

How much gene mutation that occurs can cause breast cancer?

    All women are in fact at risk of developing cancer of the breast and will increase the risk when you have the BRCA1 gene and BRCA2 mutated. As many as 55 to 65 percent of women who have the BRCA1 gene mutation And 45 percent of women with a BRCA2 gene mutation are having breast cancer at the age of 70 years.

How do I check the BRCA gene?

    There are several medical examinations that can tell if you have the BRCA genes are mutated or not. This important examination carried out especially if You have a family history of breast cancer. Have a gene mutation BRCA are indeed rare, but if you can not confirm whether in the family you've had breast cancer or cancer of the uterus, then you better check gen. But if you don't have the history in the family, then there is very little to you have the gene.

HER2 gene mutation

    Breast cancer does not occur simply because the inherited gene mutation, but gene mutation can occur by itself in the body of the woman who until recently unknown cause. Gene human epidermal growth receptor 2 or HER2 gene is a receptor protein to be functional in cells of the breast and plays a role in the increase in breast cell growth. Every woman has her menarche HER2 genes in cells.

    In normal circumstances, HER2 is also responsible for repairing damaged cells and multiply cells in the body. However, when the gene is mutated, the cells then grew due to the uncontrollable and HER2 causes cells turn into cancer cells. According to the Mayo Clinic, at least 1 in 5 women who have experienced breast cancer have HER2 genes are mutated. This gene is not derived from the parent, therefore have close relatives who have HER2 positive does not increase the risk for developing cancer of the breast or have HER2 in the body.

Other risk factors for breast cancer

    The descendants of only one of the risk factors that cause the occurrence of breast cancer. A variety of other factors that can increase the risk of developing breast cancer is age, race and ethnicity, the first menstrual period at the age of less than 12 years, menopause after age 55 years, using contraception, hormone therapy, as well as experiencing obesity and overweight. Therefore, it is better if you do a breast exam on a regular basis by way of grasping your breasts and feel if there are bumps or not. This can improve early detection of the incidence of breast cancer.